• Amenities
  • Rooms
  • More info
  • Reviews
Hotel

21C Museum Hotel St Louis

9/10 from 939 reviews
Amenities

  • Fitness facilities

  • Free WiFi

See all amenities
Where you'll be
Choose your room

Check in

Nov 14th 2025

Check out

Nov 15th 2025

Travelers

1 guest
  • Deluxe Room, 1 King Bed

    • 309 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 King Bed

    More details

    Not available

  • Luxury Double Room, 2 Queen Beds

    • 423 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 4

    • 2 Queen Beds

    More details

    Not available

  • Room (Bunk Bed)

    • 237 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 Twin Bunk Bed

    More details

    Not available

  • Loft, 2 Queen Beds

    • 431 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 4

    • 2 Queen Beds

    More details

    Not available

  • Deluxe Room, Accessible (Accessible)

    • 269 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 King Bed

    More details

    Not available

  • Suite, 1 King Bed (21C)

    • 1119 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 King Bed

    More details

    Not available

  • Suite, 1 King Bed (Library)

    • 732 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 King Bed

    More details

    Not available

  • Luxury Suite, 1 King Bed

    • 549 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 King Bed

    More details

    Not available

  • Deluxe Room, 1 Double Bed, Accessible

    • 388 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 4

    • 1 Double Bed

    More details

    Not available

  • Deluxe Suite, 1 Double Bed, Accessible

    • 517 sq ft

    • Fitness facilities

    • Free WiFi

    • Sleeps 2

    • 1 Double Bed

    More details

    Not available

About this property
21C Museum Hotel St Louis

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of City Museum and Enterprise Center. This luxury hotel is 0.6 mi (1 km) from St. Louis Union Station and 0.7 mi (1.1 km) from America's Center Convention Complex.

Languages

English

Policies
Check-in

Check-in between 4:00 PM - 11:00 AM

Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property.

Other instructions
  • Extra-person charges may apply and vary depending on property policy
  • Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
  • Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
  • This property accepts credit cards; cash is not accepted
  • Safety features at this property include a smoke detector and outdoor lighting
Property payment types

American Express, Mastercard, Visa, Cash not accepted, Debit cards not accepted

Important information
Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras
  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know
  • Reservations are required for massage services. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation.
  • This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly).
Other information
General
  • No rollaway/extra beds available
  • No cribs (infant beds) available
  • LGBTQIA+ friendly
  • Professional property host/manager
Pets
  • Pets allowed
  • Only dogs are allowed
  • Service animals are allowed
  • Service animals are exempt from fees/restrictions